changes in bone biological markers after treatment of iranian diabetic patients with pioglitazone: no relation to polymorphism of ppar- î³ (pro12ala)

نویسندگان

fatemeh namvaran department of pharmacology, college of medicine, tehran university of medical sciences, tehran, iran

parvaneh rahimi-moghaddam department of pharmacology, college of medicine, tehran university of medical sciences, tehran, iran

negar azarpira transplant research center, shiraz university of medical sciences, shiraz, iran

mohammad hossein dabbaghmanesh department of endocrinology, college of medicine and endocrinology and metabolism research center, shiraz university of medical sciences, shiraz, iran

چکیده

background: thiazolidinediones (tzds) improves insulin sensitivity by activating the peroxisome proliferator-activated receptor γ (ppar-g). we aimed to study any association between variation in bone biochemical markers and single nucleotide polymorphism (snp) in ppar- γ (pro12ala) and investigate if these genetic variants affect bone turnover markers in iranian diabetic population before and after treatment with pioglitazone. materials and methods: a total of 101 patients (type 2 diabetic (t2d) were treated for 12 weeks with pioglitazone (15 mg/day). bone biological markers, osteocalcin, and c-terminal telopeptide of type 1 collagen (ctx) were measured before and after pioglitazone therapy. we genotyped 128 nondiabetic controls and 101 t2d patients as well. pro12ala polymorphism in ppar- γ was done by real-time polymerase chain reaction (rt-pcr) using taqman assay. results: there were statistically significant differences in allele frequencies of pro12ala while comparing the controls with t2d subjects. ala frequency was 7 vs 3%, p = 0.036 and genotypic frequency of pro/ala was 5.94 vs 14.06%, p = 0.04. after treatment, the homeostasis model of assessment of insulin resistance (homa-ir) as a maker of insulin resistance was significantly decreased ( p < 0.001). in respect of bone turnover markers, ctx values decreased and osteocalcin significantly increased. ( p < 0.001). conclusion: our findings did not reveal a significant association between this polymorphism and bone turnover markers after pioglitazone treatment. the reduced insulin resistance might be the reason that ctx values decreased and osteocalcin increased significantly after short-term pioglitazone treatment. these findings suggest the need for further studies on the possible role of insulin in regulation of bone metabolism.

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منابع مشابه

changes in bone biological markers after treatment of iranian diabetic patients with pioglitazone: no relation to polymorphism of ppar-î³ (pro12ala)

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Changes in bone biological markers after treatment of Iranian diabetic patients with pioglitazone: No relation to polymorphism of PPAR-γ (Pro12Ala)

BACKGROUND Thiazolidinediones (TZDs) improves insulin sensitivity by activating the peroxisome proliferator-activated receptor γ (PPAR-g). We aimed to study any association between variation in bone biochemical markers and single nucleotide polymorphism (SNP) in PPAR-γ (Pro12Ala) and investigate if these genetic variants affect bone turnover markers in Iranian diabetic population before and aft...

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Polymorphism of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes.

The peroxisome proliferator-activated receptor γ (PPARγ) has important effects on insulin sensitivity, obesity and diabetes. Pioglitazone improves insulin sensitivity by activating PPARγ. In view of inter-individual variability in therapeutic response to pioglitazone, this study was designed to search for an association between type 2 diabetes mellitus and Pro12Ala single-nucleotide polymorphis...

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عنوان ژورنال:

journal of research in medical sciences

جلد ۱۸، شماره ۴، صفحات ۲۷۷-۰

کلمات کلیدی

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